1-Ethylpiperazine → HCID 22036503, compound

HRID 493275Notes

Reaction equation

HRID 493275 reaction equation
Cl[C:2]1[C:7]([O:8][CH:9]([CH3:20])[CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])=[N:6][CH:5]=[CH:4][N:3]=1.[CH2:21]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[CH3:22]>>[CH2:21]([N:23]1[CH2:28][CH2:27][N:26]([C:2]2[C:7]([O:8][CH:9]([CH3:20])[CH2:10][O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[O:18][CH3:19])=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:25][CH2:24]1)[CH3:22]

Participants

3

Reactant 2

HCID 791961-EthylpiperazineHCID 22036298HCID 22036298, compound

Product 1

HCID 22036503HCID 22036503, compound

Procedure

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-[2-(2-methoxyphenoxy)-1-methylethoxy]pyrazine* (150 mg, 0.51 mmol) and N-ethylpiperazine (222 mg, 1.94 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 127 mg (67%) of the title product. HRMS m/z calcd for C20H28N4O3 (M)+372 2161, found 372.2174. Anal. (C20H28N4O3) C, H, N

Workup

  1. extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record
ord-ee420fc563e0426dbde4743ef2839aae
Source dataset
uspto-grants-2009_05
Patent number
US07534794B2

Reaction notes

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