Piperazine → 3-(1-Piperazinyl)-2,6,7-trichloroquinoxaline

HRID 493315Notes

Reaction equation

HRID 493315 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[C:17](Cl)=[N:16][C:15]2[C:10](=[CH:11][C:12]([Cl:20])=[C:13]([Cl:19])[CH:14]=2)[N:9]=1>CCO>[N:1]1([C:17]2[C:8]([Cl:7])=[N:9][C:10]3[C:15]([N:16]=2)=[CH:14][C:13]([Cl:19])=[C:12]([Cl:20])[CH:11]=3)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 40971682,3,6,7-Tetrachloroquinoxaline

Product 1

HCID 220362453-(1-Piperazinyl)-2,6,7-trichloroquinoxalineYield 69%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Piperazine (0.69 g, 8.06 mmol) was added to a stirred suspension of 2,3,6,7-tetrachloroquinoxaline (1.08 g, 4.03 mmol) in EtOH (125 mL) at room temperature. The mixture was stirred at room temperature for 8 h and filtered to give the product as a pale yellow solid yield 0.88 g (69%); mp >300° C. MS m/z 316/318 (M)+.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-c258b8edda0c498c97cc8e71316b329c
Source dataset
uspto-grants-2009_05
Patent number
US07534794B2

Reaction notes

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