(e)-3-{5-[3,4-Bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]-2-thienyl}pent-2-en-1-ol → HCID 88011784, compound

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Reaction Steps

2.74 g (5.1 mmol) of (E)-3-{5-[3,4-bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]-2-thienyl}pent-2-en-1-ol are dissolved in 80 mL of dichloromethane and placed under a nitrogen atmosphere. 4.45 g (51 mmol) of manganese dioxide are added and the medium is stirred for 14 hours. After filtration and then evaporation, a yellow oil is obtained. The crude product (2.9 g) is the expected aldehyde, obtained in a quantitative yield.

Provenance & Evidence