1-Chloroethyl chloroformate → 1-(3-Chloro-2-pyrazinyl)-cis-2,6-dimethylpiperazine, Hydrochloride

HRID 493331Notes

Reaction equation

HRID 493331 reaction equation
C([N:8]1[CH2:13][C@@H:12]([CH3:14])[N:11]([C:15]2[C:20]([Cl:21])=[N:19][CH:18]=[CH:17][N:16]=2)[C@@H:10]([CH3:22])[CH2:9]1)C1C=CC=CC=1.ClC(OC(Cl)C)=O>>[ClH:21].[Cl:21][C:20]1[C:15]([N:11]2[C@H:10]([CH3:22])[CH2:9][NH:8][CH2:13][C@@H:12]2[CH3:14])=[N:16][CH:17]=[CH:18][N:19]=1

Participants

3

Reactant 2

HCID 5213051-Chloroethyl chloroformateHCID 536601384-Benzyl-1-(3-chloro-2-pyrazinyl)-cis-2,6-dimethylpiperazine

Product 1

HCID 1317274451-(3-Chloro-2-pyrazinyl)-cis-2,6-dimethylpiperazine, Hydrochloride

Procedure

The title compound was prepared by treating the product obtained in Step 2 with 1-chloroethyl chloroformate according to the procedure described in Example 1 78, Step 3. The crude product was purified by column chromatography on silica using CHCl3/MeOH/NH4OH (95:5.0.2, followed by 90:10:0.5) as eluent to give 0.50 g(8% over two steps) of the free base of the title compound as a colorless oil. An analytical sample was precipitated as its HCl salt with HCl/ether: mp 199-200° C. Anal. (C10H15ClN4.HCl) C, H, N

Workup

  1. customThe title compound was prepared
  2. customThe crude product was purified by column chromatography on silica

Sources & evidence

ORD record
ord-6d169c2b00064a19b1e394e064bfe097
Source dataset
uspto-grants-2009_05
Patent number
US07534794B2

Reaction notes

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