1-Chloroethyl chloroformate → 1-(3-Chloro-2-pyrazinyl)-cis-2,6-dimethylpiperazine, Hydrochloride

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Reaction Steps

The title compound was prepared by treating the product obtained in Step 2 with 1-chloroethyl chloroformate according to the procedure described in Example 1 78, Step 3. The crude product was purified by column chromatography on silica using CHCl3/MeOH/NH4OH (95:5.0.2, followed by 90:10:0.5) as eluent to give 0.50 g(8% over two steps) of the free base of the title compound as a colorless oil. An analytical sample was precipitated as its HCl salt with HCl/ether: mp 199-200° C. Anal. (C10H15ClN4.HCl) C, H, N

Provenance & Evidence