反应详情

温度

80 °C

9.3 g (23 mmol) of dimethyl 4-{(E)-2-[5-(2-ethyl-[1,3]dioxolan-2-yl)-2-thienyl]vinyl}phthalate are dissolved in 150 mL of dioxane and 1 mL of triethylamine is then added. The mixture is degassed using a stream of nitrogen and 9.3 g of 5% palladium-on-charcoal are then added to the reaction medium. A positive pressure of hydrogen is maintained in the reaction medium for 5 hours, with heating at 80° C. After cooling and then filtration through Celite and evaporation, the desired product is obtained in the form of a yellow oil (m=9.4 g; Y=100%).

1. customThe mixture is degassed
2. additionare then added to the reaction medium
3. temperatureA positive pressure of hydrogen is maintained in the reaction medium for 5 hours
4. temperatureAfter cooling
5. filtrationfiltration
6. customthrough Celite and evaporation