(3-Carboxypropyl)(triphenyl)phosphanium bromide → (e)-5-{5-[2-(3,4-Bis(tert-butyldimethylsilanyloxy-methyl)phenyl)ethyl]-2-thienyl}-4-heptenoic acid

Participants

Reaction Steps

In a manner similar to that of Example 6(i), by reaction of 5.08 g (9.5 mmol) of 1-{5-[2-(3,4-bis(tert-butyldimethylsilanyloxymethyl)phenyl)ethyl]-2-thienyl}-1-propanone with 6.1 g (14 mmol) of (3-carboxypropyl)triphenylphosphonium bromide and 3.1 g (28 mmol) of potassium tert-butoxide, the desired product is obtained in the form of a yellow oil (m=2.7 g; Y=48%).

Provenance & Evidence