Water → HCID 57681491, compound

HRID 493407Notes

Reaction equation

HRID 493407 reaction equation
Br[C:2]([CH2:26][CH3:27])([CH2:24][CH3:25])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18](=[O:23])[C:19](Br)([CH3:21])[CH3:20])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)=[O:4].[OH-:28].[Na+].[OH2:30]>ClCCl.CC[N+](CC1C=CC=CC=1)(CC)CC.[Cl-]>[CH2:24]([C:2]([OH:30])([CH2:26][CH3:27])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18](=[O:23])[C:19]([OH:28])([CH3:21])[CH3:20])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)=[O:4])[CH3:25]

Participants

6

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 67074012HCID 67074012, compound

Product 1

HCID 57681491HCID 57681491, compound

Reagents, catalysts & solvents 2

HCID 66133Benzyl triethylammonium chlorideCatalyst2×HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 29.15 g (0.0587 mol) of 2-bromo-1-{4-[4-(2-bromo-2-methyl-propionyl)-phenoxy]-phenyl}-2-ethyl-butane-1-one dissolved in 60 ml of dichloromethane, 16.88 g (0.211 mol) of 50% NaOH and 291.5 mg of 50% BTEAC were added. The reaction was refluxed for 3 h, adding every 30′, 291.5 mg of BTEAC, then diluted with water and dichloromethane.

Workup

  1. temperatureThe reaction was refluxed for 3 h

Sources & evidence

ORD record
ord-297892acd2e148c2836bf05eeb225c8e
Source dataset
uspto-grants-2009_05
Patent number
US07534880B2

Reaction notes

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