Bromide ion → HCID 67073634, compound

HRID 493408Notes

Reaction equation

HRID 493408 reaction equation
[BrH:1].[Br:2][C:3]([CH3:28])([CH3:27])[C:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:20])=[CH:15][CH:14]=2)=[CH:8][CH:7]=1)=[O:5].[Br-]>ClCCl>[Br:2][C:3]([CH3:28])([CH3:27])[C:4]([C:6]1[CH:7]=[CH:8][C:9]([O:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([C:21]3([Br:1])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:20])=[CH:15][CH:14]=2)=[CH:10][CH:11]=1)=[O:5]

Participants

5

Reactant 3

HCID 259Bromide ionHCID 260Hydrogen BromideHCID 67073633HCID 67073633, compound

Product 1

HCID 67073634HCID 67073634, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A drop of 48% HBr was added to a solution of 2.7 g (6.29 mmol) of 2-bromo-1-[4-(4-cyclohexancarbonyl-phenoxy)-phenyl]-2-methyl-propan-1-one dissolved in 60 ml of dichloromethane; 0.322 ml (6.29 mmol) of bromide dissolved in 5 ml of dichloromethane were added drop wise, in 15′. After 3 h, the organic phase was washed with water and with a sodium metabisulphite solution, separated, dried on sodium sulphate and evaporated in vacuum obtaining 3.2 g of product as a yellow oil.

Workup

  1. additionwere added drop wise
  2. washthe organic phase was washed with water and with a sodium metabisulphite solution
  3. customseparated
  4. customdried on sodium sulphate
  5. customevaporated in vacuum

Sources & evidence

ORD record
ord-6abd4be467bc456fa5ebdfc3212fe823
Source dataset
uspto-grants-2009_05
Patent number
US07534880B2

Reaction notes

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