Dimethylamine → HCID 67073528, compound

HRID 493416Notes

Reaction equation

HRID 493416 reaction equation
Br[CH:2]([CH2:24][CH3:25])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18](=[O:23])[C:19]([OH:22])([CH3:21])[CH3:20])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)=[O:4].[CH3:26][NH:27][CH3:28].C1COCC1>C(OCC)C>[CH3:26][N:27]([CH3:28])[CH:2]([CH2:24][CH3:25])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18](=[O:23])[C:19]([OH:22])([CH3:21])[CH3:20])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)=[O:4]

Participants

5

Reactant 3

HCID 674DimethylamineHCID 8028TetrahydrofuranHCID 86608749HCID 86608749, compound

Product 1

HCID 67073528HCID 67073528, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 7.9 g (0.0195 mol) of 2-bromo-1-{4-[4-(2-hydroxy-2-methyl-propionyl)-phenoxy]-phenyl}-butan-1-one in diethyl ether was added drop wise to a solution of 58.5 ml of dimethylamine 2M in THF (0.117 mol), maintaining the temperature between 0° C. and 5° C. After one night the reaction was diluted with ether, washed three times with water, dried with sodium sulphate and evaporated obtaining 7.47 g of an oil used without purification in the following step.

Workup

  1. temperaturemaintaining the temperature between 0° C. and 5° C
  2. washwashed three times with water
  3. dry with materialdried with sodium sulphate
  4. customevaporated

Sources & evidence

ORD record
ord-b33d7a524958465bba6b17c1f07cb42f
Source dataset
uspto-grants-2009_05
Patent number
US07534880B2

Reaction notes

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