反应详情

温度

100 °C

6-Methoxy quinoline (15 g, 0.094 mol) was dissolved in acetic acid (97 ml) and treated with hydrogen peroxide (37 ml). The mixture was stirred to 100° C. for 2 hours. After evaporation to dryness 100 ml of water was added to the residue until a precipitate appears. Filtration and washing with water gives a yellow precipitate that is dried under vacuum to yield 13.5 g of the title compound as a light yellow solid (82%). MS (m/e): 176.3 (M+H)+.

1. customAfter evaporation to dryness 100 ml of water
2. additionwas added to the residue until a precipitate
3. filtrationFiltration
4. washwashing with water
5. customgives a yellow precipitate that
6. customis dried under vacuum