Chlorodifluoromethane → (((Difluoromethyl)sulfanyl)methyl)benzene

HRID 493447Notes

Reaction equation

HRID 493447 reaction equation
[OH-].[Na+].[CH2:3]([SH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH:11](Cl)([F:13])[F:12]>O>[F:12][CH:11]([S:10][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[F:13]

Participants

5

Reactant 3

HCID 6372ChlorodifluoromethaneHCID 7509Benzyl mercaptanHCID 14798Sodium Hydroxide

Product 1

HCID 11557371(((Difluoromethyl)sulfanyl)methyl)benzeneYield 75%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

One equivalent of 40% by weight of sodium hydroxide in water was mixed with one equivalent of benzyl mercaptan with R-22 (1.1 molar equivalents) at 60° C. for 1 h. The tests are carried out in a 500 ml Hastelloy reactor at an autogenous pressure at 60° C. The pressure is 3.5 bar. A chemical yield of 75%, by quantitative determination by 19F NMR, is obtained over two tests carried out under the same conditions.

Workup

  1. customThe tests are carried out in a 500 ml Hastelloy reactor at an autogenous pressure at 60° C
  2. customA chemical yield of 75%, by quantitative determination by 19F NMR, is obtained over two tests

Sources & evidence

ORD record
ord-07802569d7904630a50f7c8531ad77ca
Source dataset
uspto-grants-2009_05
Patent number
US07534906B2

Reaction notes

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