Hydrochloric Acid → HCID 68860648, compound

HRID 493510Notes

Reaction equation

HRID 493510 reaction equation
[ClH:1].[CH3:2][O:3][C:4](=[O:27])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([NH:19]C(OC(C)(C)C)=O)=[CH:15][CH:14]=2)=[CH:9][CH:8]=1>O1CCOCC1>[Cl-:1].[CH3:2][O:3][C:4](=[O:27])[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:18]=[CH:17][C:16]([NH3+:19])=[CH:15][CH:14]=2)=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68860367HCID 68860367, compound

Product 1

HCID 68860648HCID 68860648, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

4 N HCl in dioxane (6.2 mL, 10 equiv) was added to a solution of (4′-tert-butoxycarbonylamino-biphenyl-4-yloxy)-acetic acid methyl ester (220 mg, 0.62 mmol), prepared in the previous step, in dioxane and the reaction stirred at room temperature for 2 h. The solid that formed was collected by filtration, rinsed with ethyl acetate and dried under reduced pressure to give 4′-(2-methoxy-2-oxoethoxy)-1,1′-biphenyl-4-aminium chloride (135 mg, 85%) as a white solid.

Workup

  1. customThe solid that formed
  2. filtrationwas collected by filtration
  3. washrinsed with ethyl acetate
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-0e33c7c452ec4debb7503f802c266eed
Source dataset
uspto-grants-2009_05
Patent number
US07534894B2

Reaction notes

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