反应详情

温度

120 °C

4′-Methoxy-4-nitro-biphenyl (4.55 g, 19.8 mmol), prepared in the previous step, in a mixture of glacial acetic acid plus 65 mL of 48% HBr was heated at approximately 120° C. until the reaction was complete by TLC. The reaction was concentrated under reduced pressure and the residue partitioned between diethyl ether and water. The organic layer was separated, dried (Na2SO4) and the solvent removed under reduced pressure to give 4′-hydroxy-4-nitro-biphenyl.

1. concentrationThe reaction was concentrated under reduced pressure
2. customthe residue partitioned between diethyl ether and water
3. customThe organic layer was separated
4. dry with materialdried (Na2SO4)
5. customthe solvent removed under reduced pressure