(3-Carboxypropyl)(triphenyl)phosphanium bromide → (e)-5-{4-[2-(3,4-Bis(tert-butyldimethylsilanyloxy-methyl)phenyl)ethyl]-2-thienyl}-4-heptenoic acid

Participants

Reaction Steps

In a manner similar to that of Example 6(i), by reaction of 3 g (5.6 mmol) of 1-{4-[2-(3,4-bis(tert-butyldimethylsilanyloxymethyl)phenyl)ethyl]-2-thienyl}-1-propanone with 3.6 g (8.4 mmol) of (3-carboxy-propyl)triphenylphosphonium bromide and 1.9 g (17 mmol) of potassium tert-butoxide, the desired product is obtained in the form of a yellow oil (m=1.7 g, Y=50%).

Provenance & Evidence