反应详情

27 g (76 mmol) of dimethyl 4-(3-bromo-5-thienylmethoxy)phthalate are dissolved in 200 mL of anhydrous THF. This solution is added dropwise to a suspension of 4 g (183 mmol) of lithium borohydride in 50 mL of THF. The reaction medium is refluxed for 24 h and then cooled and poured onto 200 g of ice. After extraction with ether and then chromatography on a column of silica (eluent: 5 heptane/5 ethyl acetate), the desired product is obtained in the form of a yellow oil (m=22.1 g; Y=88%).

1. temperatureThe reaction medium is refluxed for 24 h
2. temperaturecooled
3. extractionAfter extraction with ether