Trifluoroacetic acid → Trifluoroacetic acid

HRID 493618Notes

Reaction equation

HRID 493618 reaction equation
COC1C=C(OC)C=CC=1C[N:6]1[C:11]2[CH:12]=[CH:13][CH:14]=[N:15][C:10]=2[CH2:9][N:8]([CH:16]2[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]2)[C:7]1=[O:29].[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>>[C:38]([OH:40])([C:37]([F:42])([F:41])[F:36])=[O:39].[NH:19]1[CH2:18][CH2:17][CH:16]([N:8]2[CH2:9][C:10]3[N:15]=[CH:14][CH:13]=[CH:12][C:11]=3[NH:6][C:7]2=[O:29])[CH2:21][CH2:20]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22293253tert-Butyl 4-[1-(2,4-dimethoxybenzyl)-2-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 222933043-Piperidin-4-yl-3,4-dihydropyrido[3,2-d]pyrimidin-2(1H)-one

Procedure

tert-Butyl 4-[1-(2,4-dimethoxybenzyl)-2-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate (0.10 g, 0.21 mmol) was dissolved in trifluoroacetic acid (5 mL) and stirred overnight. The reaction was concentrated to afford the bis-TFA salt of the title compound (0.048 g). MS 233.2 (M+1).

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-3db53319bfb14f628ebb9e824ea3ee08
Source dataset
uspto-grants-2009_05
Patent number
US07534784B2

Reaction notes

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