Trifluoroacetic acid → Trans-[1-(2-methoxyethyl)-2-oxo-6-phenylazepan-3-yl]acetic acid

HRID 493666Notes

Reaction equation

HRID 493666 reaction equation
FC(F)(F)C(O)=O.C([CH:12]([C@H:16]1[CH2:22][CH2:21][C@H:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:19][N:18]([CH2:29][CH2:30][O:31][CH3:32])[C:17]1=[O:33])[C:13]([O-:15])=[O:14])(C)(C)C>ClCCl>[CH3:32][O:31][CH2:30][CH2:29][N:18]1[CH2:19][C@@H:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:21][CH2:22][C@H:16]([CH2:12][C:13]([OH:15])=[O:14])[C:17]1=[O:33]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86595045(trans)-Tert-butyl[1-(2-methoxyethyl)-2-oxo-6-phenylazepan-3-yl]acetate

Product 1

HCID 66939309Trans-[1-(2-methoxyethyl)-2-oxo-6-phenylazepan-3-yl]acetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (1 mL) was added to a solution (trans)-tert-butyl[1-(2-methoxyethyl)-2-oxo-6-phenylazepan-3-yl]acetate (170 mg, 0.47 mmol) in dichloromethane (3 mL). After 2 h, the solution was concentrated. MS 306 (M+1).

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-15013dfa8f3b45e3ba83b5746373f738
Source dataset
uspto-grants-2009_05
Patent number
US07534784B2

Reaction notes

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