Aluminium lithium hydride → (e)-3-{5-[3,4-Bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]-3-thienyl}pent-2-en-1-ol

Participants

Reaction Steps

In a manner similar to that of Example 7(b), by reaction of 2.3 g (3.8 mmol) of ethyl (E)-3-{5-[3,4-bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]-3-thienyl}-2-pentenoate with 180 mg (4.7 mmol) of lithium aluminium hydride, the desired product (m=2.1 g; Y=100%) is obtained in the form of a colourless oil.

Provenance & Evidence