HCID 178482543, compound → HCID 178482542, compound

Participants

Reaction Steps

tert-Butyl 1-(3-((6-chloro-2-naphthyl)sulfonyl)propanoyl)-4-(((2Z)-3-methyl-2-(methylimino)-2,3-dihydro-1,3-thiazol-4-yl)methyl)piperazine-2-carboxylate (4.1 g) obtained in Example 23b) was dissolved in concentrated hydrochloric acid (15 mL) and mixed at room temperature for 1 hour. The reaction solution was concentrated, and then water was removed from the residue by azeotropy with toluene (30 mL), to give the title compound (4.2 g) as a white powder.

Provenance & Evidence