HCID 178482543, compound → HCID 178482542, compound

HRID 493704Notes

Reaction equation

HRID 493704 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([CH2:15][CH2:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([CH2:25][C:26]3[N:27]([CH3:33])/[C:28](=[N:31]/[CH3:32])/[S:29][CH:30]=3)[CH2:21][CH:20]1[C:34]([O:36]C(C)(C)C)=[O:35])=[O:18])(=[O:14])=[O:13])[CH:6]=[CH:5]2>Cl>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([CH2:15][CH2:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([CH2:25][C:26]3[N:27]([CH3:33])/[C:28](=[N:31]/[CH3:32])/[S:29][CH:30]=3)[CH2:21][CH:20]1[C:34]([OH:36])=[O:35])=[O:18])(=[O:14])=[O:13])[CH:6]=[CH:5]2

Participants

3

Reactant 1

HCID 178482543HCID 178482543, compound

Product 1

HCID 178482542HCID 178482542, compoundYield 299%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

tert-Butyl 1-(3-((6-chloro-2-naphthyl)sulfonyl)propanoyl)-4-(((2Z)-3-methyl-2-(methylimino)-2,3-dihydro-1,3-thiazol-4-yl)methyl)piperazine-2-carboxylate (4.1 g) obtained in Example 23b) was dissolved in concentrated hydrochloric acid (15 mL) and mixed at room temperature for 1 hour. The reaction solution was concentrated, and then water was removed from the residue by azeotropy with toluene (30 mL), to give the title compound (4.2 g) as a white powder.

Workup

  1. additionmixed at room temperature for 1 hour
  2. concentrationThe reaction solution was concentrated
  3. customwater was removed from the residue by azeotropy with toluene (30 mL)

Sources & evidence

ORD record
ord-caa54348b1d8425984104dd55dab85e7
Source dataset
uspto-grants-2009_05
Patent number
US07534887B2

Reaction notes

Loading…