Ammonia → 3-Cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amine

HRID 493874Notes

Reaction equation

HRID 493874 reaction equation
Cl[C:2]1[C:3]2[N:4]([C:8]([CH:12]3[CH2:15][CH2:14][CH2:13]3)=[N:9][C:10]=2[I:11])[CH:5]=[CH:6][N:7]=1.[NH3:16]>CC(O)C>[CH:12]1([C:8]2[N:4]3[CH:5]=[CH:6][N:7]=[C:2]([NH2:16])[C:3]3=[C:10]([I:11])[N:9]=2)[CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 426093648-Chloro-3-cyclobutyl-1-iodoimidazo[1,5-a]pyrazine

Product 1

HCID 426093653-Cyclobutyl-1-iodoimidazo[1,5-a]pyrazin-8-amine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
115 °C

Procedure

A Parr bomb containing 8-chloro-3-cyclobutyl-1-iodoimidazo[1,5-a]pyrazine (759 mg, 2.3 mmol) in IPA (100 mL) was saturated with NH3(g) for 5 min at 0° C. then sealed and heated at 115° C. for 38 h. The reaction mixture was then concentrated under reduced pressure, partitioned between DCM (200 mL) and H2O (50 mL) and extracted with DCM (50 mL). Combined organic fractions were washed with brine, dried (Na2SO4) and concentrated under reduced pressure to provide the title compound as a white solid; 1H NMR (400 MHz, CDCl3) δ 7.13 (d, J=4.8 Hz, 1H), 7.01 (d, J=5.2 Hz, 1H), 5.63 (br, 2H), 3.73 (quintetd, J=0.8 Hz, 8.4 Hz, 1H), 2.60-2.38 (m, 4H), 2.20-1.90 (m, 2H); MS (ES+): m/z 315.9 (100) [MH+]; HPLC: tR=1.75 min (OpenLynx, polar—5 min).

Workup

  1. customthen sealed
  2. concentrationThe reaction mixture was then concentrated under reduced pressure
  3. custompartitioned between DCM (200 mL) and H2O (50 mL)
  4. extractionextracted with DCM (50 mL)
  5. washCombined organic fractions were washed with brine
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-51720be4b5704858965a9fb80b8fec78
Source dataset
uspto-grants-2009_05
Patent number
US07534797B2

Reaction notes

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