反应详情

温度

80 °C

To a mixture of 40 ml of acetic acid and 40 ml of water was added 2.2 g of iron powder, and the temperature was increased to 80° C. To the mixture was added 3.0 g of methyl [2-(5-acetylamino-4-fluoro-2-nitrophenoxy)phenoxy]acetate, and the mixture was heated at reflux for 30 minutes. The mixture was then poured into water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium bicarbonate solution, dried over magnesium sulfate, and then concentrated to give 2.01 g of methyl [2-(5-acetylamino-2-amino-4-fluorophenoxy)phenoxy]acetate.

1. temperaturethe mixture was heated
2. temperatureat reflux for 30 minutes
3. extractionthe mixture was extracted with ethyl acetate
4. washThe organic layer was washed with water and saturated aqueous sodium bicarbonate solution
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated