Selenium Dioxide → HCID 14000966, compound

HRID 493980Notes

Reaction equation

HRID 493980 reaction equation
[CH3:1][C:2]1[C:3](=[O:12])[NH:4][C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[Se](=O)=[O:14]>O1CCOCC1>[O:12]=[C:3]1[NH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:11]=[C:2]1[CH:1]=[O:14]

Participants

4

Reactant 2

HCID 24007Selenium DioxideHCID 263843-Methylquinoxalin-2-ol

Product 1

HCID 14000966HCID 14000966, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 3-methyl-1H-quinoxalin-2-one (0.5 g) and selenium dioxide (0.728 g, 2.1 eq) in dry dioxane (33 mL) was stirred at reflux under nitrogen for 30 min. After cooling, the dark-brown mixture was concentrated under reduced pressure and the residue was purified by FC (AcOEt) to give the title compound as an orange solid.

Workup

  1. temperatureat reflux under nitrogen for 30 min
  2. temperatureAfter cooling
  3. concentrationthe dark-brown mixture was concentrated under reduced pressure
  4. customthe residue was purified by FC (AcOEt)

Sources & evidence

ORD record
ord-1003818235e048dab10f76f9c95c3806
Source dataset
uspto-grants-2009_05
Patent number
US07538109B2

Reaction notes

Loading…