2-Chloropyridine-4-boronic acid → [1-(2-Chloro-pyridin-4-yl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-methanone

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Reaction Steps

In analogy to the procedure described for the synthesis of example 5, the title compound was synthesized from (1,1-dioxo-thiomorpholin-4-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (Example 2) and 2-chloropyridine-4-boronic acid. The desired product was obtained in a yield of 8% as an off-white solid. MS (m/e): 531.5 (M+, 100%).

Provenance & Evidence