Guanidine → HCID 23020407, compound

HRID 494023Notes

Reaction equation

HRID 494023 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]2[CH:14]=[CH:15][C:16](=O)[N:17](C)[CH:18]=2)=[CH:4][N:3]=1.[Cl:21]C1N=CC(C(=CN(C)C)C(C2OC=CC=2)=O)=CC=1.NC(N)=N>>[Cl:21][C:16]1[N:17]=[CH:18][C:13]([C:5]2[C:6]([C:8]3[O:9][CH:10]=[CH:11][CH:12]=3)=[N:7][C:2]([NH2:1])=[N:3][CH:4]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 3520GuanidineHCID 9814006HCID 9814006, compoundHCID 74013297HCID 74013297, compound

Product 1

HCID 23020407HCID 23020407, compound

Procedure

The process for preparing 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1H)-one disclosed in patent document 1 is, as shown in the reaction scheme below, a method of allowing 2-(6-chloro-3-pyridyl)-3-dimethylamino-1-(2-furyl)-2-propene-1-one to react with guanidine to afford 5-(6-chloro-3-pyridyl)-4-(2-furyl)-2-pyrimidinylamine, oxidizing this to afford 5-[2-amino-4-(2-furyl)-5-pyrimidinyl]-1,2-dihydro-2-pyridinone, and then methylating this.

Sources & evidence

ORD record
ord-de0bcf1047e346d5aaacdafa6e22e77b
Source dataset
uspto-grants-2009_05
Patent number
US07538117B2

Reaction notes

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