反应详情

A mixture of {5-[(2R)-2-oxiranyl]-2-[(phenylmethyl)oxy]phenyl}formamide (WO 0276933) (200 mg) and dibenzylamine (0.75 ml) were heated in a microwave oven at 150° for 30 min. The mixture was allowed to cool to 20° and was purified on a silica SPE bond elut cartridge (10 g) using a gradient of 0% to 50% EtOAc in cyclohexane (Gradmaster™). The appropriate fractions were evaporated in vacuo and the residue further purified by mass-directed autopreparative HPLC to give the title compound (123 mg). LCMS RT=2.75 min.

1. temperaturewere heated in a microwave oven at 150° for 30 min
2. temperatureto cool to 20°
3. customwas purified on a silica SPE bond elut cartridge (10 g)
4. customThe appropriate fractions were evaporated in vacuo
5. customthe residue further purified by mass-directed autopreparative HPLC