2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → Ethyl 6-(4-fluorophenyl)-2-methylpyridine-3-carboxylate

HRID 494180Notes

Reaction equation

HRID 494180 reaction equation
CN([CH:4]([CH3:14])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=O)C.[NH2:15]/[C:16](/[CH3:23])=[CH:17]\[C:18]([O:20][CH2:21][CH3:22])=[O:19]>>[F:13][C:10]1[CH:9]=[CH:8][C:7]([C:5]2[CH:4]=[CH:14][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:16]([CH3:23])[N:15]=2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 18755062HCID 18755062, compound

Product 1

HCID 11345961Ethyl 6-(4-fluorophenyl)-2-methylpyridine-3-carboxylate

Procedure

The title compound was prepared from dimethylamino-(4-fluorophenyl)propan-1-one and ethyl 3-aminocrotonate using the general procedure outlined in D18. MS (ES): MH+ 260.

Sources & evidence

ORD record
ord-9b3ff070b454430ca3ff0a600fe0c8a5
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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