4-tert-Butylbenzoic acid → 4-tert-Butyl-N-quinolin-7-yl-benzamide

HRID 494257Notes

Reaction equation

[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:12]([C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13]>>[C:12]([C:16]1[CH:17]=[CH:18][C:19]([C:20]([NH:1][C:2]2[CH:11]=[C:10]3[C:5]([CH:6]=[CH:7][CH:8]=[N:9]3)=[CH:4][CH:3]=2)=[O:21])=[CH:23][CH:24]=1)([CH3:15])([CH3:13])[CH3:14]

Participants

Reactant 2

HCID 74034-tert-Butylbenzoic acid

HCID 113777-Aminoquinoline

Product 1

HCID 576826704-tert-Butyl-N-quinolin-7-yl-benzamide

Procedure

Using the procedure outlined in Example 45, the title compound was prepared from 7-aminoquinoline (D55) (30 mg, 21 mmol) and 4-tert -butylbenzoic acid (45 mg, 0.25 mmol) as a yellow solid. MS(ES): MH+ 305, M-H+ 303

Sources & evidence

ORD record: ord-e9f6325a8bbb4b358b594a67956e8162
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538121B2

Reaction notes

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