7-Aminoquinoline → 6-(4-Fluorophenyl)-2-methyl-N-quinolin-7-yl-nicotinamide

HRID 494273Notes

Reaction equation

HRID 494273 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[C:21]([CH3:28])[N:20]=2)=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:27]=[CH:26][C:22]([C:23]([NH:1][C:2]3[CH:11]=[C:10]4[C:5]([CH:6]=[CH:7][CH:8]=[N:9]4)=[CH:4][CH:3]=3)=[O:24])=[C:21]([CH3:28])[N:20]=2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 242777906-(4-Fluorophenyl)-2-methylpyridine-3-carboxylic acid

Product 1

HCID 445789886-(4-Fluorophenyl)-2-methyl-N-quinolin-7-yl-nicotinamide

Procedure

Using the procedure outlined in Example 45, the title compound was prepared from 7-aminoquinoline (D55) (26 mg, 0.8 mmol) and 6-(4-fluorophenyl)-2-methylnicotinic acid (D24) (50 mg, 0.22 mmol) as a white solid. MS(ES): MH+ 358, M-H+ 356.

Sources & evidence

ORD record
ord-9bcdbd1012104c0bb3859ac734515f0a
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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