(1,1'-Biphenyl)-4-carboxylic acid → HCID 44415687, compound

HRID 494285Notes

Reaction equation

HRID 494285 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[C:13]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:18]=[CH:17][C:16]([C:19](O)=[O:20])=[CH:15][CH:14]=1>>[O:12]=[C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][C:2]([NH:1][C:19]([C:16]3[CH:17]=[CH:18][C:13]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)=[CH:14][CH:15]=3)=[O:20])=[CH:3][CH:4]=2)[NH:9]1

Participants

3

Reactant 2

HCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 189415427-Aminoquinolin-2(1H)-one

Product 1

HCID 44415687HCID 44415687, compound

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-amino-1H-quinolin-2-one (D89) (30 mg, 0.19 mmol) and 4-biphenylcarboxylic acid (44 mg, 0.22 mmol) as an off-white solid. 1H NMR (400 MHz, DMSO) δ (ppm): 11.80 (br, 1H), 10.58 (br, 1H), 8.09 (d, 2H), 8.04 (d, 1H), 7.85 (m, 3H), 7.77 (d, 2H), 7.62 (d, 1H), 7.52 (m, 3H), 7.44 (t, 1H), 6.39 (d, 1H).

Sources & evidence

ORD record
ord-d37fdcb32f19454096fed0e58cf668e7
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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