6-Phenylnicotinic acid → HCID 57682680, compound

HRID 494286Notes

Reaction equation

HRID 494286 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[C:13]1([C:19]2[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][N:20]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[O:12]=[C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][C:2]([NH:1][C:23](=[O:24])[C:22]3[CH:26]=[CH:27][C:19]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[N:20][CH:21]=3)=[CH:3][CH:4]=2)[NH:9]1

Participants

3

Reactant 2

HCID 1201186-Phenylnicotinic acidHCID 189415427-Aminoquinolin-2(1H)-one

Product 1

HCID 57682680HCID 57682680, compound

Procedure

Using the procedure outlined in Example 56, the title compound was prepared from 7-amino-1H-quinolin-2-one (D89) (30 mg, 0.19 mmol) and 6-phenylnicotinic acid (D48) (45 mg, 0.22 mmol) as an off-white solid. 1H NMR (400 MHz, DMSO) δ (ppm): 11.80 (br, 1H), 10.73 (br, 1H), 9.21 (d, 1H), 8.42 (dd, 1H), 8.18 (m, 3H), 8.01 (d, 1H), 7.84 (d, 1H), 7.64 (d, 1H), 7.53 (m, 4H), 6.40 (dd, 1H).

Sources & evidence

ORD record
ord-281b2efc433b4147ae9f965feb7dfdc2
Source dataset
uspto-grants-2009_05
Patent number
US07538121B2

Reaction notes

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