Cyclohexanone → 3,3-dimethyl-1-oxa-4-azaspiro[4.5]decane

HRID 494296Notes

Reaction equation

[C:1]1(=[O:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:8][C:9]([CH3:13])([CH3:12])[CH2:10]O>>[CH3:10][C:9]1([CH3:13])[NH:8][C:1]2([CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[O:7][CH2:12]1

Participants

Reactant 2

HCID 7967Cyclohexanone

HCID 118072-Amino-2-methyl-1-propanol

Product 1

HCID 2769673,3-dimethyl-1-oxa-4-azaspiro[4.5]decane

Procedure

Reaction of cyclohexanone with 2-amino-2-methyl-1-propanol to form 3,3-dimethyl-1-oxa-4-azaspiro[4.5]decane.

Sources & evidence

ORD record: ord-6dd9000b2a854766b049499e9586edf7
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538130B2

Reaction notes

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