Trifluoroacetic acid → HCID 68830743, compound

HRID 494307Notes

Reaction equation

HRID 494307 reaction equation
C([NH:8][C@H:9]1[CH2:13][CH2:12][C@@H:11]([CH2:14][N:15]2[CH:23]=[C:22]3[C:17]([CH:18]=[CH:19][CH:20]=[CH:21]3)=[N:16]2)[CH2:10]1)(OC(C)(C)C)=O.[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]>ClCCl>[F:27][C:26]([F:29])([F:28])[C:24]([OH:30])=[O:25].[N:16]1[N:15]([CH2:14][C@@H:11]2[CH2:12][CH2:13][C@H:9]([NH2:8])[CH2:10]2)[CH:23]=[C:22]2[C:17]=1[CH:18]=[CH:19][CH:20]=[CH:21]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 18453484HCID 18453484, compound

Product 1

HCID 68830743HCID 68830743, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Deprotection of N1-BOC-(1S,3R)-3-(2H-indazol-2-ylmethyl)cyclopentan-1-amine (400 mg, 1.27 mmol), the more polar isomer from Step 1, Example 67, using TFA (3 ml) in dry dichloromethane (3 ml) as described in Example 1, Step 2 gave 273 mg of the amine as its TFA salt, which was used as such for the coupling reaction.

Sources & evidence

ORD record
ord-4bc86f7910c04aed80b1e74d83ae338c
Source dataset
uspto-grants-2009_05
Patent number
US07538128B2

Reaction notes

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