Trifluoroacetic acid → HCID 18453453, compound

HRID 494308Notes

Reaction equation

HRID 494308 reaction equation
[N:1]1([CH2:10][C@H:11]2[CH2:15][CH2:14][C@@H:13]([NH2:16])[CH2:12]2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][NH:2]1.[C:17]([OH:23])([C:19]([F:22])([F:21])[F:20])=[O:18]>ClCCl>[F:20][C:19]([F:22])([F:21])[C:17]([OH:23])=[O:18].[N:1]1([CH2:10][C@H:11]2[CH2:15][CH2:14][C@@H:13]([NH2:16])[CH2:12]2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][NH:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 18453454HCID 18453454, compound

Product 1

HCID 18453453HCID 18453453, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Deprotection of N1-BOC-[(3S,1R)-3-(2H-benzo[d][1,2,3]triazol-1-ylmethyl)cyclopentylamine (420 mg, 1.33 mmol), the less polar isomer from Step 1 using TFA (2 ml) in dry dichloromethane (2 ml) as described in Example 1, Step 2 gave 438 mg of the amine as its TFA salt, which was used as such for the next step.

Sources & evidence

ORD record
ord-634aa91b3092431db9c9919cbde3e082
Source dataset
uspto-grants-2009_05
Patent number
US07538128B2

Reaction notes

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