Trifluoroacetic acid → HCID 68836076, compound

HRID 494309Notes

Reaction equation

HRID 494309 reaction equation
[N:1]1[N:2]([CH2:10][C@H:11]2[CH2:15][CH2:14][C@@H:13]([NH2:16])[CH2:12]2)[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[C:17]([OH:23])([C:19]([F:22])([F:21])[F:20])=[O:18]>>[F:20][C:19]([F:22])([F:21])[C:17]([OH:23])=[O:18].[N:1]1[N:2]([CH2:10][C@H:11]2[CH2:15][CH2:14][C@@H:13]([NH2:16])[CH2:12]2)[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68836077HCID 68836077, compound

Product 1

HCID 68836076HCID 68836076, compound

Procedure

Deprotection of N1-BOC-[(3S,1R)-3-(2H-benzo[d][1,2,3]triazol-2-ylmethyl)cyclopentylamine (420 mg, 1.33 mmol), the more polar isomer obtained from Example 70, Step 1 using TFA (2 ml) in dry dichloromethane (2 ml) as described in Example 1, Step 2 gave 438 mg (100%) of the amine as its TFA salt, which was used as such for the next step.

Sources & evidence

ORD record
ord-a33b7384531340bdab40242e0e30a4e6
Source dataset
uspto-grants-2009_05
Patent number
US07538128B2

Reaction notes

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