HCID 57683030, compound → HCID 57683016, compound

HRID 494322Notes

Reaction equation

HRID 494322 reaction equation
[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[N:9]([CH3:28])[CH:10]=[C:11]([C:13]([C:15]3[C:16](C4C=CC(F)=CC=4)=[N:17][O:18][C:19]=3[CH3:20])=[O:14])[CH:12]=2)=[O:7])C[CH2:2]1.C(NC(C1NC=C(C(C2C([C:48]3[CH:53]=[CH:52][CH:51]=[C:50]([F:54])[CH:49]=3)=NOC=2C)=O)C=1)=O)C#C>>[CH2:4]([NH:5][C:6]([C:8]1[N:9]([CH3:28])[CH:10]=[C:11]([C:13]([C:15]2[C:16]([C:48]3[CH:53]=[CH:52][CH:51]=[C:50]([F:54])[CH:49]=3)=[N:17][O:18][C:19]=2[CH3:20])=[O:14])[CH:12]=1)=[O:7])[C:1]#[CH:2]

Participants

3

Reactant 2

HCID 57683030HCID 57683030, compoundHCID 57683060HCID 57683060, compound

Product 1

HCID 57683016HCID 57683016, compoundYield 43%

Procedure

According to the procedure described for the synthesis of 4-(5-methyl-3-(4-fluorophenyl)-isoxazole-4-carbonyl)-1-methyl-pyrrole-2-carboxylic acid (cyclopropylmethyl)-amide (Example 229, step 3), the title compound was synthesized from 4-[5-methyl-3-(3-fluorophenyl)-isoxazole-4-carbonyl)-1H-pyrrole-2-carboxylic acid prop-2-ynylamide (example 179) in 43% yield as white solid. (m/e): 366.1 (M+1; 100%).

Sources & evidence

ORD record
ord-a78de0f9d2114c07a8574f0c5f01e036
Source dataset
uspto-grants-2009_05
Patent number
US07538132B2

Reaction notes

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