HCID 57480100, compound → HCID 57683003, compound

HRID 494324Notes

Reaction equation

HRID 494324 reaction equation
[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[N:9]([CH3:28])[CH:10]=[C:11]([C:13]([C:15]3[C:16]([C:21]4[CH:26]=[CH:25][C:24](F)=[CH:23][CH:22]=4)=[N:17][O:18][C:19]=3[CH3:20])=[O:14])[CH:12]=2)=[O:7])[CH2:3][CH2:2]1.C1(NC(C2NC=C(C(C3C(C4C=CC=C([F:55])C=4)=NOC=3C)=O)C=2)=O)CCC1>>[CH:4]1([NH:5][C:6]([C:8]2[N:9]([CH3:28])[CH:10]=[C:11]([C:13]([C:15]3[C:16]([C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([F:55])[CH:22]=4)=[N:17][O:18][C:19]=3[CH3:20])=[O:14])[CH:12]=2)=[O:7])[CH2:2][CH2:3][CH2:1]1

Participants

3

Reactant 2

HCID 57480100HCID 57480100, compoundHCID 57683030HCID 57683030, compound

Product 1

HCID 57683003HCID 57683003, compoundYield 34.2%

Procedure

According to the procedure described for the synthesis of 4-(5-methyl-3-(4-fluorophenyl)-isoxazole-4-carbonyl)-1-methyl-pyrrole-2-carboxylic acid (cyclopropylmethyl)-amide (Example 229, step 3), the title compound was synthesized from 4-[5-methyl-3-(3-fluorophenyl)-isoxazole-4-carbonyl)-1H-pyrrole-2-carboxylic acid cyclobutylamide (example 174) in 34.2% yield as white solid. (m/e): 382.1 (M+1; 100%).

Sources & evidence

ORD record
ord-37d5a65fad5a4ed4bda2a1dc282d5e23
Source dataset
uspto-grants-2009_05
Patent number
US07538132B2

Reaction notes

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