Cyclopropanemethanamine → HCID 57683039, compound

HRID 494325Notes

Reaction equation

HRID 494325 reaction equation
[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[NH:9][CH:10]=[C:11]([C:13]([C:15]3[C:16]([C:21]4[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=4)=[N:17][O:18][C:19]=3[CH3:20])=[O:14])[CH:12]=2)=[O:7])[CH2:3][CH2:2]1.[F:28]C1C=C(C2C(C(C3C=C(C(=O)C(Cl)(Cl)Cl)NC=3)=O)=C(C)ON=2)C=CC=1F.C1(CN)CC1>>[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[NH:9][CH:10]=[C:11]([C:13]([C:15]3[C:16]([C:21]4[CH:22]=[CH:23][C:24]([F:27])=[C:25]([F:28])[CH:26]=4)=[N:17][O:18][C:19]=3[CH3:20])=[O:14])[CH:12]=2)=[O:7])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 75646CyclopropanemethanamineHCID 57682986HCID 57682986, compound2×HCID 57683183HCID 57683183, compound

Product 1

HCID 57683039HCID 57683039, compound

Procedure

According to the procedure described for the synthesis of 4-(5-methyl-3-(4-fluorophenyl)-isoxazole-4-carbonyl)-1H-pyrrole-2-carboxylic acid (cyclopropylmethyl)-amide (example 229, step 2), the title compound has been synthesized from 4-[3-(3,4-difluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-2-trichloroacetyl-1H-pyrrole (intermediate 19) and cyclopropylmethylamine (commercially available) in 35.8 yield. (m/e): 386.1 (MH+; 100%).

Sources & evidence

ORD record
ord-fc47efa4ac694ed68921e4ac10709eff
Source dataset
uspto-grants-2009_05
Patent number
US07538132B2

Reaction notes

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