反应详情

To a solution of methyl 2-[(2′-cyanobiphenyl-4-yl)methylamino]-3-methoxycarbonylaminobenzoate (10.5 g) in methanol (100 ml) was added NaOMe (10 g), and the mixture was heated under reflux for 20 hours. The reaction mixture was neutralized with 1N-HCl and concentrated to dryness. The residue was extracted with chloroform-water. The organic layer was washed with water, dried and evaporated to dryness. The resulting crystals were recrystallized from chloroform-methanol to afford colorless needles (8.67 g, 89%), m.p. 250-253° C.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 20 hours
3. concentrationconcentrated to dryness
4. extractionThe residue was extracted with chloroform-water
5. washThe organic layer was washed with water
6. customdried
7. customevaporated to dryness
8. customThe resulting crystals were recrystallized from chloroform-methanol