反应详情

To a solution of ethyl 2-chloro-1-[(2′-cyanobiphenyl-4-yl)methyl]benzimidazole-7-carboxylate (1.0 g) in ethanol (30 ml) was added NaOEt (0.17 g) and the mixture was heated under reflux for 1 hour. The reaction mixture was concentrated to dryness. The resultant residue was dissolved in ethyl acetate and the solution was washed with water, and then dried. After evaporation of the solvent, the residue was purified by column chromatography on silica gel to give the title compound as colorless crystals (0.37 g, 70%). 1H-NMR and IR spectra indicate that the product according to this working Example is completely identical with that obtained in Working Example 4.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1 hour
3. concentrationThe reaction mixture was concentrated to dryness
4. dissolutionThe resultant residue was dissolved in ethyl acetate
5. washthe solution was washed with water
6. customdried
7. customAfter evaporation of the solvent
8. customthe residue was purified by column chromatography on silica gel