反应详情

To a solution of [4-(4′-trifluoromethylbiphenyl-2-carbonylamino)piperidin-1-yl]acetic acid ethyl ester (595 mg) obtained in Example 8c) in tetrahydrofuran-methanol (1:2; 10.2 mL) was added 1M aqueous lithium hydroxide (6.8 mL), and the mixture was stirred at room temperature for 6 hours. The reaction solution was concentrated in vacuo and 2N hydrochloric acid was added to the residue to adjust the pH to about 3, thereby crystals were precipitated. The crystals were collected by filtration, washed with cold water and dried in vacuo to give the title compound (411 mg).

1. concentrationThe reaction solution was concentrated in vacuo and 2N hydrochloric acid
2. additionwas added to the residue
3. customcrystals were precipitated
4. filtrationThe crystals were collected by filtration
5. washwashed with cold water
6. customdried in vacuo