HRID494405

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22236963

Diethyl (hydroxymethyl)(phenyl)propanedioate

C14H18O5

结构：O=C(O)CN1CCC(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)CC1

HCID23033209

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(COC(=O)CN1CCC(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)CC1)(C(=O)OCC)c1ccccc1

HCID57503491

未命名化合物

PROCEDURE

实验过程

The [4-(4′-trifluoromethylbiphenyl-2-carbonyl-amino)piperidin-1-yl]acetic acid obtained in Example 8d) and the 2-hydroxymethyl-2-phenylmalonic acid diethyl ester obtained in Example 1-2a) were subjected to reactions similar to those in Example 1g) to give the title compound (90 mg) (see Table 58).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-23c2ca8d09934cd599eac1c185ca2cef
来源数据集: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07538140B2
来源说明: uspto-grants-2009_05

反应 SMILES

[F:1][C:2]([F:29])([F:28])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([C:15]([NH:17][CH:18]3[CH2:23][CH2:22][N:21]([CH2:24][C:25]([OH:27])=[O:26])[CH2:20][CH2:19]3)=[O:16])=[CH:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[CH2:30]([O:32][C:33](=[O:48])[C:34]([CH2:46]O)([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH3:31]>>[CH2:38]([O:37][C:35](=[O:36])[C:34]([C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)([CH2:46][O:26][C:25](=[O:27])[CH2:24][N:21]1[CH2:20][CH2:19][CH:18]([NH:17][C:15]([C:10]2[C:9]([C:6]3[CH:7]=[CH:8][C:3]([C:2]([F:1])([F:28])[F:29])=[CH:4][CH:5]=3)=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:16])[CH2:23][CH2:22]1)[C:33]([O:32][CH2:30][CH3:31])=[O:48])[CH3:39]