Diethyl 2-(hydroxymethyl)-2-phenylmalonate → 2-Phenyl-2-(2-{4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]piperidin-1-yl}acetoxymethyl)malonic acid diethyl ester

Participants

Reaction Steps

The [4-(4′-trifluoromethylbiphenyl-2-carbonyl-amino)piperidin-1-yl]acetic acid obtained in Example 8d) and the 2-hydroxymethyl-2-phenylmalonic acid diethyl ester obtained in Example 1-2a) were subjected to reactions similar to those in Example 1g) to give the title compound (90 mg) (see Table 58).

Provenance & Evidence