反应详情

To a stirred solution of 1-[3,5-bis(benzyloxy)phenyl]ethanone (5 g, 15.04 mmol) in tetrahydrofuran (60 mL) and methanol (35 mL) was added tetrabutylammonium tribromide (7.25 g, 15.04 mmol) in tetrahydrofuran (20 mL) at room temperature. The reaction mixture was stirred for 24 hours and the solvent removed in vacuo. The residue was dissolved in ethyl acetate (100 mL) and washed with water (2×50 mL). The combined organic extracts were dried over magnesium sulfate and concentrated to afford the desired compound as a yellow oil in quantitative yield.

1. customthe solvent removed in vacuo
2. dissolutionThe residue was dissolved in ethyl acetate (100 mL)
3. washwashed with water (2×50 mL)
4. dry with materialThe combined organic extracts were dried over magnesium sulfate
5. concentrationconcentrated