HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 494467Generated: October 30, 2026
Hydrochloric Acid → 4-hydroxy-1,1-dimethyl-2(1H)-naphthalenone
https://huagongshe.com/reaction/494467
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 1-hydroxy-4,4-dimethyl-3-oxo-3,4-dihydro-2-naphthalenecarboxylate | HCID 57604805 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-hydroxy-1,1-dimethyl-2(1H)-naphthalenone | HCID 12369102 | — |
Reaction Steps
A solution of the product of Example 9E (2.25 g, 8.65 mmol) in dioxane (50 mL) was treated with 1 N HCl solution (60 mL) and the mixture was stirred at reflux for 6 hours, cooled to 25° C., diluted with ethyl acetate and water. The organic layer was washed with water (2×) and saturated sodium chloride solution (1×), dried(Na2SO4), filtered and concentrated in vacuo. The residue was triturated with ether and filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07538105B2 |
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| Source dataset | uspto-grants-2009_05 |
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| ORD ID | ord-e132b16ef53f422793d779137ae29935 |
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| Source note | uspto-grants-2009_05 |
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