反应详情

温度

25 °C

A solution of the product of Example 9E (2.25 g, 8.65 mmol) in dioxane (50 mL) was treated with 1 N HCl solution (60 mL) and the mixture was stirred at reflux for 6 hours, cooled to 25° C., diluted with ethyl acetate and water. The organic layer was washed with water (2×) and saturated sodium chloride solution (1×), dried(Na2SO4), filtered and concentrated in vacuo. The residue was triturated with ether and filtered.

1. temperatureat reflux for 6 hours
2. washThe organic layer was washed with water (2×) and saturated sodium chloride solution (1×), dried(Na2SO4)
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customThe residue was triturated with ether
6. filtrationfiltered