Hydrochloric Acid → 3-(7-Amino-1,1-dioxido-4h-1,2,4-benzothiadiazin-3-yl)-1-(5,5-dimethylhexyl)-4-hydroxy-1-methylnaphthalen-2(1h)-one hydrochloride

Participants

Reaction Steps

A solution of Example 37A (0.775 g, 1.33 mmol) in 4M hydrochloric acid in 1,4-dioxane (10 mL) was stirred at 25° C. for 1 hour. The solution was concentrated in vacuo and the residue was triturated in diethyl ether to give the title compound (0.374 g, 54%).

Provenance & Evidence