Hydrochloric Acid → HCID 136397171, compound

HRID 494548Notes

Reaction equation

HRID 494548 reaction equation
[CH3:1][C:2]([CH3:41])([CH3:40])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]1([CH3:39])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([OH:17])=[C:9]([C:18]2[NH:23][C:22]3[CH:24]=[CH:25][C:26]([NH:28]C(=O)OC(C)(C)C)=[CH:27][C:21]=3[S:20](=[O:37])(=[O:36])[N:19]=2)[C:8]1=[O:38].[ClH:42]>O1CCOCC1>[ClH:42].[NH2:28][C:26]1[CH:25]=[CH:24][C:22]2[NH:23][C:18]([C:9]3[C:8](=[O:38])[C:7]([CH2:6][CH2:5][CH2:4][CH2:3][C:2]([CH3:1])([CH3:40])[CH3:41])([CH3:39])[C:16]4[C:11]([C:10]=3[OH:17])=[CH:12][CH:13]=[CH:14][CH:15]=4)=[N:19][S:20](=[O:37])(=[O:36])[C:21]=2[CH:27]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136384826HCID 136384826, compound

Product 1

HCID 136397171HCID 136397171, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of Example 37A (0.775 g, 1.33 mmol) in 4M hydrochloric acid in 1,4-dioxane (10 mL) was stirred at 25° C. for 1 hour. The solution was concentrated in vacuo and the residue was triturated in diethyl ether to give the title compound (0.374 g, 54%).

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. customthe residue was triturated in diethyl ether

Sources & evidence

ORD record
ord-101f566ba8e7493da3bab333682700d3
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

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