Sodium Hydroxide → HCID 25260422, compound

HRID 494567Notes

Reaction equation

HRID 494567 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C@:5]([CH3:17])([CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:4](=[O:18])[C:3]=1[C:19]1[NH:24][C:23]2[CH:25]=[CH:26][C:27]([NH:29][S:30]([CH3:33])(=[O:32])=[O:31])=[CH:28][C:22]=2[S:21](=[O:35])(=[O:34])[N:20]=1.[OH-].[Na+:37]>O>[CH3:17][C@:5]1([CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([O-:1])=[C:3]([C:19]2[NH:24][C:23]3[CH:25]=[CH:26][C:27]([NH:29][S:30]([CH3:33])(=[O:32])=[O:31])=[CH:28][C:22]=3[S:21](=[O:35])(=[O:34])[N:20]=2)[C:4]1=[O:18].[Na+:37]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135442740HCID 135442740, compound

Product 1

HCID 25260422HCID 25260422, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the product of Example 40I (2.12 g) in water (10 mL) and treated with 0.997N sodium hydroxide solution (0.969 mL, 0.966 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.412 g, 79%). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.46 (m, 1H) 0.69 (m, 6H) 0.80 (m, 1H) 1.29 (m, 1H) 1.38 (m, 3H) 1.72 (m, 1H) 2.14 (m, 1H) 2.90 (m, 3H) 7.34 (m, 6H) 8.05 (m, 1H) 15.42 (m, 1H). MS (ESI−) m/z 516 (M−H)−.

Sources & evidence

ORD record
ord-cc3ab9fe9bdb4c46929aa7e52c6ee09f
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

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